Nicotine may harm human embryos at the single-cell level — ScienceDaily

Nicotine induces widespread adverse effects on human embryonic development at the level of individual cells, researchers report February 28th in the journal Stem Cell Reports. Single-cell RNA sequencing of human embryonic stem cell (hESC)-derived embryoid bodies revealed that 3 weeks of nicotine exposure disrupts cell-to-cell communication, decreases cell survival, and alters the expression of genes…

How prostate cancer becomes treatment resistant — ScienceDaily

The development of effective anti-androgen therapies for prostate cancer is a major scientific advance. However, some men who receive these targeted treatments are more likely to develop a deadly treatment-resistant prostate cancer subtype called neuroendocrine prostate cancer (NEPC). No effective treatment for NEPC exists. Now, scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP) have…

Pan-filovirus T-cell vaccine protects mice from Ebola and Marburg — ScienceDaily

Vaccines that induce protective T-cell responses could protect against members across the filovirus family, according to a study published February 28 in the open-access journal PLOS Pathogens by Tomáš Hanke of the University of Oxford, Bette Korber of the Los Alamos National Laboratory, and colleagues. Developing an effective vaccine against filovirus outbreaks is an important…

Researchers observe an unusual quantum Hall effect in the old three-dimensional material — ScienceDaily

Researchers at The University of Manchester in the UK, led by Dr Artem Mishchenko, Prof Volodya Fal’ko and Prof Andre Geim, have discovered the quantum Hall effect in bulk graphite — a layered crystal consisting of stacked graphene layers. This is an unexpected result because the quantum Hall effect is possible only in so-called two-dimensional…

The particles, discovered in mice, may activate immune function and could play a role in preventing metabolic disorders — ScienceDaily

Researchers have discovered that fat tissue releases a lipid-filled particle that has a role in immune function and metabolism. The study, in mice, was published online in the journal Science. Why it matters Obesity appears to activate the immune system, contributing to type 2 diabetes, nonalcoholic fatty liver disease, and other disorders. Understanding how fat…