Genetic variants linked to metabolic and crystallization pathways may increase risk — ScienceDaily

Researchers have discovered new genetic factors that likely contribute to the development of kidney stones. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), may be useful for predicting individuals’ risk of developing kidney stones and for identifying new targets for prevention and treatment. Increasing numbers…

Biochemical switches identified that could be triggered to treat muscle, brain disorders — ScienceDaily

St. Jude Children’s Research Hospital scientists have found that the enzymes ULK1 and ULK2 play a key role in breaking down cell structures called stress granules, whose persistence leads to toxic buildup of proteins that kill muscle and brain cells. Such buildup is central to the pathology of three related diseases: inclusion body myopathy (IBM),…

How they fare — ScienceDaily

Although the majority of patients who have blood cancers are older adults, they make up only a small percentage of participants in the clinical trials that lead to new therapies. That’s because the standard research methods used in oncology (cancer medicine) are not ideal for identifying certain vulnerabilities linked to aging, such as having multiple…